The term “modafinil 400 mg” means that it is a high dose therapy using modafinil, a prescription drug used to increase wakefulness in adults with excessive sleepiness due to certain sleep disorders. Modafinil is FDA approved to enhance wakefulness in patients with narcolepsy, obstructive sleep apnea (OSA) characterized with persistent daytime sleepiness even after treating the underlying airway obstruction, and SWSD (Shift Work Sleep Disorder). The main aim of modafinil is to assist people to stay awake during the day while they undergo treatments for other conditions associated with excessive sleepiness.

Modafinil acts through altering certain brain pathways which regulate sleep-wake cycles. Even though the exact mechanism of its action is unknown, there is sufficient scientific evidence showing that this drug affects neurotransmitters involved in promoting alertness and wakefulness. It makes this drug to be categorized as a wake-promoting agent rather than a stimulant. There are various studies which have evaluated modafinil in sleep medicine as an improvement of alertness.

For all medically-approved indications, the recommended dosage is 200 mg once per day. Sometimes, a doctor can recommend the use of the double daily dose amounting 400 mg according to individual patient’s response and the need for treatment. Nevertheless, research has demonstrated that doses exceeding 200 mg do not guarantee a more noticeable increase in wakefulness in most patients. The choice of a higher dose depends on certain criteria, including the nature of the diagnosed disorder, age, general health state, individual response and medication being taken at the moment.

Narcoleptic patients suffer from sudden attacks of sleepiness and uncontrolled sleepiness during the day, which affects their ability to perform work and educational duties. Modafinil allows patients to overcome daytime drowsiness and become more active. Patients suffering from obstructive sleep apnea syndrome may feel sleepy even after the therapy with CPAP or other similar treatments was applied successfully. Thus, modafinil can be used to increase alertness during the day while treating sleep apnea. In case of shift work sleep disorder, modafinil helps to stay awake during the working hours in the conditions of non-standard schedule.

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