Hydroxychloroquine is generally not linked to direct weight gain and is considered a weight-neutral medication. Unlike corticosteroids, it does not usually increase appetite or cause fluid retention. Most patients taking hydroxychloroquine for autoimmune conditions maintain stable weight, especially when the medication is used alone and as prescribed.

In some cases, people using Hydroxychloroquine 400mg may notice minor weight changes due to indirect reasons. Better control of autoimmune symptoms can improve appetite and energy levels, which may lead to slight weight gain. This change is typically related to improved health, lifestyle factors, or other medications taken alongside hydroxychloroquine rather than the drug itself.