Introduction
Celebrex (celecoxib) is a prescription medication classified as a nonsteroidal anti-inflammatory drug (NSAID). Unlike traditional NSAIDs like ibuprofen or naproxen, Celebrex 200mg is a COX-2 selective inhibitor, meaning it reduces inflammation and pain with a potentially lower risk of stomach irritation. However, like all medications, it comes with possible side effects—some mild and temporary, others serious and requiring immediate medical attention.

Introduction
Celebrex (celecoxib) is a prescription medication classified as a nonsteroidal anti-inflammatory drug (NSAID). Unlike traditional NSAIDs like ibuprofen or naproxen, Celebrex is a COX-2 selective inhibitor, meaning it reduces inflammation and pain with a potentially lower risk of stomach irritation. However, like all medications, it comes with possible side effects—some mild and temporary, others serious and requiring immediate medical attention.

This comprehensive guide will cover:

How Celebrex 200mg works

Common side effects (and when they improve)

Serious side effects that need urgent care

Who should avoid Celebrex?

How to take it safely

When to call your doctor

1. How Celebrex 200mg Works
Celebrex blocks an enzyme called cyclooxygenase-2 (COX-2), which is responsible for inflammation and pain. By selectively inhibiting COX-2 (rather than both COX-1 and COX-2 like other NSAIDs), it reduces:

Joint swelling (arthritis)

Stiffness (morning discomfort in rheumatoid arthritis)

Chronic pain (osteoarthritis, ankylosing spondylitis)

However, because it doesn’t fully block COX-1 (which protects the stomach lining), it may still cause digestive issues, though typically less severe than other NSAIDs.

2. Common Side Effects of Celebrex (Usually Mild and Temporary)
Many users experience minor side effects when starting Celebrex, but these often improve within days or weeks as the body adjusts.

A. Digestive Issues
Indigestion (upset stomach, mild heartburn)

Nausea or mild diarrhea

Gas or bloating

Why it happens: Even though Celebrex is gentler on the stomach than ibuprofen, it can still irritate the digestive tract.

What helps:
✔ Take with food or milk
✔ Avoid alcohol (increases stomach irritation)
✔ Stay hydrated

B. Dizziness or Mild Headache
Some users report lightheadedness, especially when standing up quickly.

This usually fades as the body gets used to the medication.

What helps:
✔ Rise slowly from sitting/lying down
✔ Avoid driving if dizziness is severe

C. Mild Swelling (Edema)
Celebrex can sometimes cause slight ankle or leg swelling due to fluid retention.

When to worry: If swelling is sudden, severe, or accompanied by shortness of breath (could indicate heart issues).

3. Serious Side Effects of Celebrex (When to Seek Emergency Help)
While rare, Celebrex can cause severe complications, especially with long-term use or high doses.

A. Heart Attack & Stroke Risk
Celebrex (like all NSAIDs) may increase blood pressure and raise the risk of heart attack or stroke, even in people with no prior heart disease.

The risk is higher in those with:

Existing heart conditions

High blood pressure

Long-term NSAID use

Warning Signs:
❗ Chest pain or pressure
❗ Sudden numbness in the face/arm
❗ Slurred speech (possible stroke)

B. Stomach & Intestinal Bleeding
Though less likely than with ibuprofen, Celebrex can still cause ulcers or bleeding in the stomach/intestines.

Warning Signs:
❗ Black, tarry stools (sign of digested blood)
❗ Vomiting blood or coffee-ground-like material
❗ Severe stomach pain

C. Kidney Problems
NSAIDs reduce blood flow to the kidneys, which can lead to:

Swelling in legs/feet

Urinating less than usual

Fatigue or confusion (from toxin buildup)

High-risk patients: Those with kidney disease, dehydration, or on diuretics.

D. Severe Allergic Reactions
Though rare, some people may experience:

Swelling of the face/throat (anaphylaxis)

Skin rash or blisters (Stevens-Johnson syndrome)

Wheezing or trouble breathing

Action: Stop Celebrex and seek emergency care if any allergic symptoms appear.

4. Who Should Avoid Celebrex?
Celebrex is not safe for everyone. Avoid or use with extreme caution if you have:
✔ Heart disease or prior stroke
✔ Stomach ulcers or bleeding history
✔ Kidney or liver disease
✔ Asthma attacks triggered by NSAIDs
✔ Pregnancy (especially third trimester—can harm the fetus)
✔ Allergy to sulfa drugs (Celebrex contains sulfonamide)

Always share your full medical history with your doctor before starting Celebrex.

5. How to Take Celebrex 200mg Safely
Dosage: Typically 200mg once or twice daily (varies by condition).

Take with food to reduce stomach upset.

Avoid alcohol (increases bleeding risk).

Do not combine with other NSAIDs (ibuprofen, aspirin—unless prescribed).

Regular check-ups: Blood pressure and kidney function should be monitored.

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